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Polish the English language of a scientific manuscript Ferulic acid (FA) in H9C2 cells - 30/04/2018 04:22 EDT

€30-250 EUR

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Publicado há aproximadamente 6 anos

€30-250 EUR

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The study deals with Ferulic acid (FA). We investigate its protective effect on H/R injury in H9C2 cells by inhibiting mitochondrial hyperautophagy through the PINK1/parkin pathway, protecting mitochondrial function, and inhibiting apoptosis. First, FA was detected to reduce apoptosis (CCK8 detection survival rate, TUNEL detection of apoptosis, Caspase3 protein WB expression), and secondly, increased mitochondrial function (ADP/ATP conversion rate decreased, membrane potential increased, ROS decreased) Finally, the mechanism was explored from the PINK1/pakin pathway. The mitochondrial autophagy agonist rapamycin was added and it was found that FA can antagonize the activation of rapamycin on this pathway and reduce mitochondrial autophagy. (Fluorescence probe colocalization was used to detect mitochondrial-lysosome binding levels; immunofluorescence co-localization was used to detect PINK1-HSP60, Parkin-HSP60 levels, which is the expression level of the pathway proteins on mitochondria; WB assays PINK1, Parkin, LC3II/LC3I, P62 protein expression level)
ID do Projeto: 16831702

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Ativo há 6 anos

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I am interested in working on your order; can you assign it to me? I guarantee you 100% satisfaction on the project in the following order: 6. 100% Original Paper 7. Plagiarism-free paper 8. Impeccable Grammar used 9. Instructions duly followed and adhered to 10. Coherent Transition of paragraphs
€155 EUR em 3 dias
4,9 (13 avaliações)
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Hello I offer high-quality, in-depth proofreading, editing and manuscript review. I am a native English speaker with a post-graduate degree from an English University. I have a strong academic training and background, and my command of English is excellent. I am an accomplished writer and author. I have written a PhD thesis and published papers in reputable international journals. I have taught, lectured and developed courses at university level. I have worked actively in academic research programs, preparing, writing and editing academic papers, research proposals and reports. I am well qualified for your task. My academic training was in the biological sciences, so the subject matter of your paper is familiar to me. My natural writing style is simple, fluent and lucid. I am able to structure documents logically, simply and clearly, and to express only what needs to be said with perfect language, sentence structure and grammar. I can offer positive, constructive comment on the overall arc and structure of your paper, its content and organisation, and your use of language. My fee and the delivery time are wholly negotiable. Thank you for your consideration.
€200 EUR em 4 dias
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Relevant skills possessed for this. So I can surely help. I have good grammatical skills too that will help me in the project.
€155 EUR em 3 dias
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A proposal has not yet been provided
€55 EUR em 3 dias
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After reviewing the abstract of your manuscript, i found that your work was innovative and interesting. The key steps of your project is as follows 1. You selected H/R injury H9C2 cells for establishing protective action of FA against cell apoptosis. 2. You achieved by targeting the parkin pathway by inhibiting the mitochondrial hyperautophagy. 3. You observed the positive results and monitered the antagonist action of FA using mitochondrial autophagy agonist rapamycin. 4. Used the fluorescence bio markers to monitor the mechanism and evident the observed results. Informing you that i have been working as reviewer for various internatioal journals and i can complete your work in more effectSrikanth you can search my profile in google scholar citation through my name "SRIKANTH GURRALA" Awaiting for your acceptance Regards Srikanth GURRALA
€166 EUR em 5 dias
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Bandeira do(a) NETHERLANDS
Utrecht, Netherlands
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Membro desde abr. 26, 2018

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