Setup Safe ISP Bulk Email Send System

I want to be able to send Can-Spam Compliant bulk emails for various clients without concern of ISP shutdown or impacting clients' websites/ISPs. All bonafide professional business projects, no adult, gambling, etc. Ideally, it would be a system that I can use for a number of different clients over time, each with different website landing page. I need technical consulting on how software to use to do this, where to go for an ISP, etc. Alternatively, I can use someone else's email-out program/ISP/system at a certain price per number of emails. I'm looking at sending tens of thousands of targeted emails to business list segments, not millions or to bulk lists.